WebCirculating tumour cells (CTCs) can be used to generate CTC derived explants (CDX) for the study of SCLC biology and the development of novel therapeutics. We investigated whether there are demographic or clinical predictors of the success of CDX generation, and whether CDX models are representative of the SCLC patient population. WebSCLC; BET; PARP; BMN673; GSK-525762A 1. Introduction Small cell lung cancer (SCLC) is the most aggressive type of lung cancer [ 1, 2 ]. Genome-wide analyses in SCLC specimens confirmed, in ~15% of cases, gene amplification of one of the members of the MYC gene family, MYC, MYCL, or MYCN (hereafter MYCs) [ 3, 4 ].
Molecular Characterization and Therapeutic …
Web30 Mar 2024 · Key Points. Question Do patient characteristics of smokers and never-smokers differ among patients with small cell lung carcinoma (SCLC)?. Findings In this … Web21 Dec 2024 · Lung cancer is consistently the leading cause of cancer-related death worldwide, and it ranks as the second most frequent type of new cancer cases diagnosed … the golden ratio instagram
Molecular profiles of small cell lung cancer subtypes: Therapeutic ...
Web24 Jan 2024 · Small Cell Lung Cancer (SCLC) tumors are heterogeneous mixtures of transcriptional subtypes. Understanding subtype dynamics could be key to explaining the … Web29 Mar 2024 · SCLC subsets express specific surface markers, providing potential opportunities for antibody-based targeted therapies. YAP1-driven SCLCs are notable for differential expression of the NOTCH pathway, epithelial-mesenchymal transition (EMT), and antigen-presenting machinery (APM) genes and sensitivity to mTOR and AKT inhibitors. WebSmall cell lung cancer (SCLC) is characterized by morphologic, epigenetic and transcriptomic heterogeneity. Subtypes based upon predominant transcription factor expression have been defined that,... the golden ration of the ladder networks