WebThe Folliculin tumor suppressor is a GAP for RagC/D GTPases that signal amino acid levels to mTORC1 Zhi-Yang Tsun1,2, Liron Bar-Peled#1,2, Lynne Chantranupong#1,2, Roberto Zoncu1,2, Tim Wang1,2, Choah Kim1,2, Eric Spooner1, and David M. Sabatini1,2,3 1Whitehead Institute for Biomedical Research and Massachusetts Institute of … WebNov 9, 2024 · The Rag GTPase Inhibits TORC1 in GATOR2 Mutant Drosophila and HeLa Cells (A) Co-depletions of ragA or ragC rescue the small ovary phenotype of seh1RNAi females. ragARNAi, ragCRNAi, and seh1RNAi TRiP constructs were driven by the germline-specific driver nanos-GAL4VP16. mch RNAi: mCherry-RNAi. Scale bar: 1 mm.
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WebOct 1, 2024 · The structures of RagC-S75N GDP and the RagC-T90N GDP are very similar, except that RagC-S75N GDP has helix α2 of switch I (residues 86-93) ordered in one of the two heterodimers in the crystal asymmetric unit ( Fig. 4A ), suggesting that S75N destabilizes, but does not completely disorder switch I. WebJan 25, 2024 · A complex of TFEB–RagA–RagC was obtained by co-expression of full-length TFEB (R245-247A, S211A) and Rag GTPases (RagA Q66L, RagC S75N) in human … chemistry ionic bonding worksheet answers
Genome-wide CRISPR screens identify ILF3 as a mediator of …
WebMay 31, 2013 · In vitro binding assay in which FLAG-GATOR1 was incubated with immobilized HA–glutathione S-transferase (HA-GST)–tagged RagB T54N-RagC Q120L … WebSelfridge ANGB is a strategic Air Force guard base located in the northern part of the United States, close to Mount Clemens. Its name comes after the first pilot who died in a crash … WebNov 21, 2013 · (A) Rag heterodimers containing RagCS75Ncoimmunoprecipitate the largest amount of endogenous mTORC1. Anti-FLAG immunoprecipitates were prepared from HEK293T cells expressing the indicated cDNAs. Cell lysates and immunoprecipitates were analyzed by immunoblotting for the indicated proteins. chemistry ionic bonds worksheet