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Pirh2 and p53

Webbpromote p53 degradation (Leng et al, 2003). Pirh2 is itself a p53-inducible gene product, and this dependence creates an autoregulatory feedback loop in which both the activity of p53 and the expression of Pirh2 are tightly regulated. As a short-lived protein, Pirh2 is a target for RING domain-depen-dent proteasomal degradation. Binding of ... Webb16 apr. 2024 · In the case of p53 accumulation after stress, it would induce FBXW7 expression, which in turn would reduce p53 protein to basal levels, allowing the restoring of a normal cell cycle. This feedback-based regulation has been described previously in some of the reported ubiquitin ligases that target p53: MDM2, Pirh2 and COP1 [17,18,19].

Axin determines cell fate by controlling the p53 activation

Webb17 nov. 2011 · The E3 ligase Pirh2 has been reported to polyubiquitylate p53 and to mediate its proteasomal degradation. Here, using Pirh2 deficient mice, we report that … WebbIn this study, we evaluated the prognostic value of p53, Pirh2, and L1CAM in 60 cases of EC using immunohistochemistry (IHC) and polymerase chain reaction. TP53 missense … hachfeld limited https://conestogocraftsman.com

Molecular basis of Pirh2-mediated p53 ubiquitylation - Nature

WebbResidues 240-250 in the C-terminus of the Pirh2 protein complement the function of the RING domain in self-ubiquitination of the Pirh2 protein. Abou Zeinab R, Wu H, Sergi C, Leng RP. PLoS ONE 8 e82803 (2013) The essential functions of NEDD8 are mediated via distinct surface regions, and not by polyneddylation in Schizosaccharomyces pombe. Webb湖南师范大学医学院病理教研室. 被引频次. 569. 成果数. 42. h指数. 10. g指数. 23. WebbDescription: Homo sapiens tumor protein p73 (TP73), transcript variant 8, mRNA. (from RefSeq NM_001204184) RefSeq Summary (NM_001204184): This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in … hach ferrous iron field kit

Phosphorylation of Pirh2 by Calmodulin‐dependent kinase II …

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Pirh2 and p53

Regulation of p53 Stability and Function in HCT116 Colon Cancer …

Webb12 dec. 2007 · Pirh2 ( P 53 i nduced R ING- H2 protein) is a p53 inducible E3 ligase involved in the ubiquitination of p53, while the mechanisms to regulate its activities are largely … WebbTumor Suppressor Protein p53 (4) Positron-Emission Tomography (3)

Pirh2 and p53

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Webb所属 (現在)：産業医科大学,医学部,講師, 研究分野：生物系,生物系薬学,衛生学,機能生物化学,機能生物化学, キーワード：細胞周期,癌,p27^,ユビキチン,p27,Skp2,プロテアソーム,RBタンパク質,予後,p27Kip1, 研究課題数：27, 研究成果数：119, 継続中の課題：ゲノム編集オルガノイド由来プレ ... WebbIn this study, we evaluated the prognostic value of p53, Pirh2, and L1CAM in 60 cases of EC using immunohistochemistry (IHC) and polymerase chain reaction. TP53 missense …

Webb2 sep. 2024 · 野生型p53 具有抗肿瘤作用；突变型p53 不仅没有 分子的相互作用，初步探讨Pirh2 在恶性肿瘤中可能的致 抗肿瘤效应，反而有促进肿瘤形成的作用，具有癌基因 癌机制。. 的特征。. 研究表明，在所有恶性肿瘤中，50% 以上会出 [1] 现p 53 基因突变 。. 泛素连 … Webb15 okt. 2006 · Pirh2, a recently identified ubiquitin-protein ligase, has been reported to promote p53 degradation. Pirh2 physically interacts with p53 and promotes …

Webb, Zinc finger protein 363, p53-induced RING-H2 protein, hPirh2, RCHY1, ARNIP, CHIMP, PIRH2, RNF199, ZNF363应用：WB~~1:500~1000简单描述：mouse Monoclo Webb14 juni 2007 · Pirh2 is itself a p53-inducible gene product, and this dependence creates an autoregulatory feedback loop in which both the activity of p53 and the expression of Pirh2 are tightly regulated. As a short-lived protein, Pirh2 is a target for RING domain-dependent proteasomal degradation.

WebbAbstract MDM2, Pirh2 and COP1 are important E3 ubiquitin ligases, which directly interact with p53 and target p53 for proteasome-mediated degradation. MDMX, the MDM2 …

WebbSection snippets Bone marrow stem cell reprogramming into skin cells. Pluripotent embryonic stem cells are capable of differentiating into all cell types of the body.21, 22 By contrast, adult stem cells are capable of differentiating into some or all major cell types of the tissue or organ in which they reside. bradt school lunch menuWebb17 nov. 2011 · The E3 ligase Pirh2 has been reported to polyubiquitylate p53 and to mediate its proteasomal degradation. Here, using Pirh2 deficient mice, we report that … brad truax interpolWebb维普中文期刊服务平台，是重庆维普资讯有限公司标准化产品之一，本平台以《中文科技期刊数据库》为数据基础，通过对国内出版发行的15000余种科技期刊、7000万篇期刊全文进行内容组织和引文分析，为高校图书馆、情报所、科研机构及企业用户提供一站式文献服务 … brad truelatch.comWebb15 nov. 2010 · In this regard, our Preliminary Data point to the involvement of the Pirh2 protein in p53 inhibition. Therefore, we suggest that p53 may be a novel therapeutic … brad trushinWebbAntoine Mialon studies Microbiology, Environmental Engineering, and Aerospace Engineering. bradt\\u0027s butcher leamingtonWebb29 juni 2024 · It has also been reported that CDK9 phosphorylates the Pirh2 protein and prevents the degradation of the p53 protein in CNS-derived cells . In contrast, in colon cancer cells, inhibition of CDK9 has been shown to reactivate p53 by downregulating iASPP . MDM2 is a principal regulator of p53 and has been validated as an oncotarget. bradt\\u0027s butcherWebbLatent infection is a major barrier for cure of HIV-1 infection. HIV-1 is capable of establishing latency when its host cells undergo apoptosis and initiate replication in response to this effect. HIV infection results in increased p53 expression that enhances replication in primary infection. To examine whether p53 reactivates HIV-1 replication … hach ferrous iron kit