2024 Paclitaxel glycolysis

Paclitaxel glycolysis

Author: gxgk

August undefined, 2024

WebIntegrated with the above studies, we reasonably speculated that FOXO6 may be related to paclitaxel resistance and glycolysis in HCC cells. Therefore, the biological role and …

Paclitaxel-induced painful neuropathy is associated …

WebIntegrated with the above studies, we reasonably speculated that FOXO6 may be related to paclitaxel resistance and glycolysis in HCC cells. Therefore, the biological role and mechanism of FOXO6 in paclitaxel resistance of HCC cells were investigated in the present study, aiming to provide new molecular directions and preventing resistance to ... WebThe suppression of circ_0000231 promoted paclitaxel sensitivity and apoptosis but inhibited cell proliferation, migration, and invasion, whereas overexpression of circ_0000231 had the opposite effect, indicating the role of circ_0000231 on the malignancy and PTX resistance of ovarian cancer, Importantly, the same result was also demonstrated in ... radost zivljenja

Analysis of Differential Expression Proteins of Paclitaxel-Treated …

WebFeb 29, 2024 · Therefore, this study was set out to investigate the effect of FOXO6 on glycolysis and cytotoxicity of paclitaxel in HCC cells and its potential mechanism. The levels of FOXO6 mRNA and protein were detected by qRT-PCR and Western blot, respectively. In addition, paclitaxel-resistant cell lines of HCC cells were established, whose activity was ... WebMar 15, 2024 · Paclitaxel (PTX) resistance contributes to mortality in epithelial ovarian cancer (EOC). Aerobic glycolysis is elevated in the tumor environment and may influence … WebPaclitaxel and its derivatives. Paclitaxel is a terpene isolated from yew trees in 1971 [15] and first became a medicine in 1993. Paclitaxel is a microtubule inhibitor [11] that binds to … dramarama mount oval

Long Non-Coding RNA TMPO-AS1 Promotes GLUT1-Mediated Glycolysis …

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WebPaclitaxel was originally extracted from Taxus brevifolia and is widely used in cancer treatment, such as cervical cancer, pancreatic cancer, and so on. 4,5 In the treatment of NSCLC, ... In human cells, oxidative phosphorylation and glycolysis are the two primary metabolic pathways responsible for ATP production. WebMay 14, 2024 · Although mitochondrial respiration is the primary pathway to obtain ATP in most cells, aerobic glycolysis is also essential for cancer cells as well as other highly proliferating cell types (e.g ... dramarama movie onlineWebNov 15, 2004 · If glycolysis could be blocked preferentially in malignant cells, 2DG would have potential for anti-tumor therapy. ... there is evidence in human tumor xenografts of delayed tumor growth for 2DG in combination with paclitaxel compared to paclitaxel alone and it has been reported that taxanes may enhance uptake of 2DG into malignant cells ... radost vrtic sabac

"WebKnockdown of the transcription factor Forkhead box 6 can inhibit glycolysis of hepatocellular carcinoma cells and reduce their paclitaxel resistance via inhibiting the PI3K/AKT signaling pathway . HIF-1 is a nucleoprotein secreted under hypoxia that acts as a transcription factor to regulate angiogenesis, endothelial cell migration ( 184 ... " - Paclitaxel glycolysis

Paclitaxel glycolysis

Inhibition of Lipolysis by Mercaptoacetate and Etomoxir ... - PLOS

WebFeb 29, 2024 · Therefore, this study was set out to investigate the effect of FOXO6 on glycolysis and cytotoxicity of paclitaxel in HCC cells and its potential mechanism. The … WebGAS6-AXL Inhibition by AVB-500 Overcomes Resistance to Paclitaxel in Endometrial Cancer by Decreasing Tumor Cell Glycolysis. Shaina F. Bruce, Kevin Cho, Hollie Noia, Elena Lomonosova, Elizabeth C. Stock, Alyssa Oplt, Barbara Blachut, ...

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WebAug 14, 2014 · Inhibition of glycolysis by 2-deoxy-D-glucose or koningic acid could decrease autophagy and enhance sensitivity of HeLa-R cells to paclitaxel. Moreover, glycolysis could activate HIF1-α. WebJun 1, 2024 · 2. Metabolism addiction in pancreatic cancer. 2.1. Aerobic glycolysis. Glucose metabolism is a complex process involving glycogenolysis and gluconeogenesis, both of which regulate blood glucose levels. The main function of glucose is to provide cellular energy for supporting various biochemical reactions.

WebAug 1, 2024 · Finally, treatment with AVB-500 + paclitaxel decreased multiple glycolytic metabolites, including fructose-1,6-bisphosphate (p=0.002), 3-phosphoglyceric acid (p=0.014), phosphoenolpyruvate (p=0. ... WebApr 5, 2024 · Overexpression of long non-coding RNA urothelial carcinoma associated 1 causes paclitaxel (Taxol) resistance in colorectal cancer cells by promoting glycolysis. ... Importantly, Taxol-resistant cells had a higher glycolysis rate and upregulated expression of the key glycolysis enzymes hexokinase 2 (HK2) and lactate dehydrogenase A (LDHA) …

WebMay 27, 2024 · Increased glycolysis in tumor cells is frequently associated with drug resistance. Overexpression of glucose transporter-1 (GLUT1) promotes the Warburg … WebJan 20, 2024 · Paclitaxel-resistant cancer types have been reported to develop more rapid cross-resistance to a variety of unrelated drugs. 65, 66, 67 However, the development of rapid multiplicity and reaction ...

WebOct 14, 2024 · NgBR knockdown inhibited glycolysis and promoted paclitaxel-induced apoptosis by attenuating HIF-1α expression in ER-positive breast cancer cells via NgBR …

WebAug 2, 2024 · The inhibitory effects of paclitaxel and doxorubicin were significantly enhanced when glucose concentration was decreased in the culture medium, requiring 1000-fold lesser concentration to achieve a similar degree of inhibition to that seen in glucose-containing medium. ... 2-DG is a D-glucose analogue which inhibits glycolysis … radost življenjahttp://cls.hznu.edu.cn/c/2024-11-06/2474074.shtml dr amara njWebApr 14, 2024 · Down-regulation of circKIF4A expression can reverse miR-335 and thus inhibit glycolysis in BC cells. Here, HK2 is also present as a target of the paclitaxel resistance regulatory pathway, which means that silencing HK2, on the one hand, blocks the energy source required for cancer growth, and on the other hand, enhances drug sensitivity. drama ramsWebMay 24, 2024 · Paclitaxel is an effective anticancer agent against ovarian, lung, breast, prostate, liver, gastric and pancreatic cancer. This drug has also shown beneficial effects on melanoma, head and neck ... drama ramen koreaWebApr 14, 2024 · Interestingly, miR-18a also promotes paclitaxel resistance in TNBC cells by hindering paclitaxel-induced apoptosis and suppressing the expression of Dicer, which is a processer for miRNA [231,232]. DICER promotes autophagy by inhibiting the activation of the PI3K/AKT/mTOR pathway and thus leads to cisplatin resistance non-small cell lung … dr amara nephrologueWebNov 6, 2024 · Tissue-specific study across the stem of Taxus media identifies a phloem-specific TmMYB3 involved in the transcriptional regulation of paclitaxel biosynthesis. Plant J. 103(1):95-110. Plant J. 103(1):95-110. dramarama josephine joWebPaclitaxel-induced painful neuropathy is associated with changes in mitochondrial bioenergetics, glycolysis, and an energy deficit in. dorsal root ganglia. neurons. Painful … drama rania